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Duration: 8min 46sec Views: 1800 Submitted: 17.02.2020
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The renaissance of the laboratory rabbit as a reproductive model for human health is closely related to the growing evidence of periconceptional metabolic programming and its determining effects on offspring and adult health. Advantages of rabbit reproduction are the exact timing of fertilization and pregnancy stages, high cell numbers and yield in blastocysts, relatively late implantation at a time when gastrulation is already proceeding, detailed morphologic and molecular knowledge on gastrulation stages, and a hemochorial placenta structured similarly to the human placenta. To understand, for example, the mechanisms of periconceptional programming and its effects on metabolic health in adulthood, these advantages help to elucidate even subtle changes in metabolism and development during the pre- and peri-implantation period and during gastrulation in individual embryos. Gastrulation represents a central turning point in ontogenesis in which a limited number of cells program the development of the three germ layers and, hence, the embryo proper. Newly developed transgenic and molecular tools offer promising chances for further scientific progress to be attained with this reproductive model species.

Rabbit as a reproductive model for human health

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Loosely based on the novel Who Censored Roger Rabbit? Set in a version of Hollywood where cartoon characters commonly referred as "toons" and people co-exist, the film follows Eddie Valiant , a private investigator who must exonerate Roger Rabbit , a toon who has been accused of murdering a wealthy businessman. Walt Disney Pictures purchased the film rights for the film's story in
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